PV-iSA is a comprehensive solution integrating computer-aided diagnosis and medical imaging assisted precision surgery for cancers. Based on computer vision and medical image analysis, PV-iCAD and PV-iCAS are developed to provide automated lesions location and quantitative 3D modeling, facilitating advanced clinical applications. This platform is designed to advance precision surgery by improving certainty and predictability where physicians can perform interactive analysis and pre- /peri-/post- treatment planning.